Separate self me lives from one experience to another through thoughts, feelings, perceptions and projections. Perhaps at some point one gets exhausted chasing ideas to feel better realizing the futility of it all left with a sense of hopelessness. Separation always seeks to make sense to understand, to know, dramatically fluctuating its position when it dose not know or understand.
What is makes no sense and can not be understood with stock plied knowledge by your mind nor a practice of any kind. The ending of separate self me is also the ending of all separation. What is known dose not arise from accumulative knowledge rather from other.